People talk about Groundhog Day. Bah. I'm a bit irked that nobody seems to remember Been There, Done That. This manga's plot has much more in common with that Xena episode than with the film, as in both cases (the Xena & Gabrielle story and the manga story) it's a suicide because of thwarted love that brings about the time loop.
The murder of Otome is a definite possibility ONLY if the plot goes the comedic way and the two mcs start trying to break the time loop by doing every random crazy thing they can think of — thus repeating the loop again and again hundreds and thousands of times... but I daresay that's not where the author wants to take her characters. ( ͡~ ͜ʖ ͡°)