Based on various bits of dialogue from Sakura, it seems like she's a bit of a closet "Fujoshi", she gets yaoi vibes while watching two boys struggling against each other in the Judo Tournament. And ends up becoming something of a low-key gamer/otaku after getting mixed up with the members of the gaming club.
I don't really see her as the type who would be harboring a crush on another girl. After all, we've only ever seen her expressing attraction towards male students- and she seems to be in the middle of initiating sex with her new hookup in the infirmary bed (during the Christmas Eve arc). I think she should be celebrated as a female character for being so open and assertive when it comes to her sexuality and what she wants.