I shipped Satsuki x Ryuko before I found out that they were sisters and was crushed when they revealed that. A little while later tho I realized I could still ship them and it's just a good time overall now lol
"Akko, Professor Meridies is just helping me with a magical first aid lesson. No, professor, I do NOT think she "ought to join us." Akko, I think Sucy and Lotte are looking for you. "
From my SIFAS gameplay (English version, so there's only 7 chapters and two events out, and I haven't unlocked everybody's bond- and side-stories yet), I'd say that the Nijigasaki pairings that are strongest are Anata/Ayumu, Anata/Kasumi, Ai/Rina, and Kanata/Pillow. Everybody sure is fond of Anata, though.