When I was younger, there was a kid in my class with eyes like that. He got made fun of for it early on, but by the time I left that school, everyone knew him as "the cool kid with different colored eyes," so I guess it worked out.
On a side note, Tokumi Yuiko is a God in my eyes. It's too bad I haven't seen anything original from her(?), but at the same time it's majorly cute when a doujin artist devotes themselves passionately to a series/pairing, so it's cool either way.
The anime is pretty slick too, if you're into subtext and/or ridiculously melodramatic board games.