I'll be honest, I stopped reading after a couple chapters. But I just decided to revisit it, since it's gone on longer and I thought that maybe it had matured with time and space for a more nuanced exploration of the themes introduced. I've got trans and gender non-conforming friends IRL, I fostered a trans* kid for a couple years. I think that very few comics do trans* well (some feature perfect trans* characters who always pass, others treat it as not seriously or something that needs to be fixed).
I don't really see this as a trans* comic, as it seems to focus on the cis friend more than the trans* character, by an order of magnitude. I think it's aimed at a younger audience, as it has a couple characters (the one teacher, and the wavy-haired guy) who are always right (and to a lesser extend the blonde lesbian). These characters seem to never have personal agendas that interfere with them giving insightful advice to the characters (mostly to the cis-girl, who honestly is a piece of work at the start and a good example of how not to be an ally).
That being said, I don't find the plot particularly moving, it can be summed up as "childhood friends in high school have a lot of feelings and bad boundaries" which is in part understandable as high schoolers aren't adults. Adding in gender identity issues doesn't add that much to the plot (it'd be interesting if it explored what steps Akira would have to take, and the medical treatment options for transgender youth in Japan, it does cover some issues, but mostly in terms of the parents' reaction).