What prevents it from being comedy AND yuri?
The fact that nobody is going to hook up.
This!
slightly, but visibly annoyed voice: Aha... So that explains your stance on "A Room for Two"...
I know it's a late answer which never will be seen but I'm not a native speaker and I meant with hook-up - to become a couple / being a couple and not making out / having sex.
But my stance on "A room for two" stays: it's rather Subtext than Yuri.