I don't know if it has been brought before (thread has gotten quite big) but has Y: The Last Man been mentioned?
Is a comic book series published on 2002 by DC under their Vertigo imprint. The premise is that one day all the mammal with a x chromosome on the world die due an epidemic, except by the protagonist, Yorick and his capuchine monkey Ampersand.
The series follows Yorick on his quest to found what made him inmune to the disease so the male gender can be restored. As the premise suggests, there's quite a lot of lesbian characters involved. Just keep in mind that the series deals with a dystopic setting where the aftermath of all the men dying in a male-oriented society is explored and thus, the whole thing presents all kind of lesbian characters.