Revisiting this after a few years, I think the question mark in the title might not be there to dispute the idea that this is yuri. Instead, it might be an honest question, from the POV of the trans girl. She seems to be unsure if her childhood friend, who likes women, would like her too, since she is trans (she points to herself saying "♂"). To which her friend gently affirms her gender with a smile, even saying her heart is that of a girl, and then initiates a kiss. So the story answers the question posed by the title with a resounding yes, which I find quite sweet.