Honestly, if I were in Mei's shoes (which, sadly, none of us will ever be :P) I'd choose Kaoru in a heartbeat. She and Maria are the only ones who are appealing as long-term partners. Kaoru has her shit together and already has goals and aspirations she's properly pursuing. She's a really strong person, she's fun, isn't shy or timid, and she cares about others.
Also she's very pretty. That certainly doesn't hurt.
I do wonder what the end will be like. It's set up like Mei is the center of a polycule, but I haven't really seen polyamory done "well" in manga. I can think of two examples that actually tried to go for it and neither one stuck the landing.
(In fact, they both fell flat on their faces, then proceeded to fall down several flights of stairs before rolling out the door, straight into the middle of a busy freeway during rush hour, where they were bounced around like pinballs before rocketing straight into the sun.)
I know it's been a couple months, but if you do want a manga with well done polyamory, I'd recommend "An Easy Introduction to Love Triangles (To Pass the Exam!)" Yeah it's a long title, but it actually sticks the landing and has a convincing buildup, with good dynamics between each member of the polycule.
If I were in Mei's shoes, I'd choose Kaoru because she's got a concrete plan for her life and is clearly driven. Also because she's tall and I really want her to bite me (I mean just LOOK at her teeth).