I love how ambiguous it is, as to if it's two transmascs, two transfems, or a transmasc and a transfem, or even which one is transmasc and which one is transfem. That kind of ambiguity is great. Very gender.

One of the gender bender manga is titled trans girl (トランス・ガール), so that lends some pretty solid credence to them being trans. It's clear at least that the author is aware of it.