It would be just like this series to reveal that Setsu dated Itami when she was little for like a day, and have her be number 6, and she doesn’t remember this and for some reason doesn’t know she’s an oddman.
There’s any number of ways that Setsu could be number 6 or become number 6.
My personal theory is that the game that Itami (sister) just talked about isn’t about dating her brother, and has something instead to do with proving that Setsu’s an oddman. And then the count of Itami (brother) having nine exes was just an assumption based on there being a number 11.