Here's what I imagine following the final chapter...
Shuu confesses to Youko and tells her she'll become a male to be with her. And then Youko says... "But I'm a lesbian; If you want to win me, you'd better become a female! That's why I've been pushing my blood on you after all."
Yuri goggles at warp factor 9.5 (I'll see myself out now.)
May I ask you which manga your avatar comes from?