I loved this series, watched it at least 3 times now, can't say I've had a chance to read it yet though.
Even though he reincarnated as a girl, I don't think they bring it up at all for most of the show. If you didn't know his backstory and didn't see the occasional flashback I'd dare say you'd never even know. They don't do any of the usual genderswap gags or plot lines you'd usually see. Almost as it is just matter of fact that he was reborn as a girl and there's nothing unusual or different about it.