Highly doubt that anything yuri-focused would sell well, no matter how solidly set it might be. Yuri never sells (only yuru yuri, which is due to it's comedy).
Yuri can sell well if it is in a good anime. Yuri is not a genre. Romance, Cordey and Action are. Like you said, Yuru Yuri sold well because it is a good comedy/healing anime. A Yuri romance show can sell just as well, if it is good. But even most Hetero romance shows are just horrible, why should yuri be any better? Anime writer can't into good romance.